Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 249/18 (2006.01) A61K 31/4192 (2006.01) A61K 31/437 (2006.01) A61P 31/18 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2673093

Compounds of Formula I are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

L'invention concerne des composés de formule I qui consistent en des inhibiteurs de la transcriptase inverse du VIH, V, W, X, Y, Z, R1, R2, R4, R5, R6, cycle A, cycle B, j et k étant définis dans le présent document. Les composés de formule I, et les sels et promédicaments de ceux-ci acceptables sur le plan pharmaceutique, sont utiles dans l'inhibition de la transcriptase inverse du VIH, dans la prophylaxie et le traitement d'infection par le VIH et dans la prophylaxie, le retardement de l'apparition ou de la progression, et le traitement du SIDA. Les composés et leurs sels peuvent être utilisés comme ingrédients dans des compositions pharmaceutiques, facultativement combinés à d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.

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