Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 249/12 (2006.01) A61K 31/4164 (2006.01) A61K 31/4196 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61P 31/18 (2006.01) C07D 233/84 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2496565

Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds.

Selon l'invention, différents carbonylamides sont utilisés in vitro et in vivo en tant qu'inhibiteurs non nucléosidiques d'une transcriptase inverse, et en particulier d'une transcriptase inverse du VIH. Ainsi, les composés selon l'invention peuvent être employés dans le cadre du traitement de patients infectés par le VIH. La présente invention se rapporte en outre à des compositions pharmaceutiques comprenant des doses thérapeutiquement efficaces desdits composés.

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