Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4162 (2006.01) A61K 31/4353 (2006.01) A61P 31/18 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2683046

Compounds of formula (I), wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula (I) useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

L'invention concerne des composés de formule (I), dans laquelle R1, R2, R3, R4, Ra, X, X1 et Y sont tels que définis dans le descriptif, ou des sels pharmaceutiquement acceptables desdits composés. Lesdits composés, qui inhibent la transcriptase inverse du VIH-1, constituent un moyen de prévention et de traitement des infections dues au VIH-1, et de traitement du SIDA et/ou du syndrome associé au SIDA (SAS). La présente invention concerne également des compositions contenant des composés de formule (I) utiles pour prévenir et traiter les infections par le VIH-1 et traiter le SIDA et/ou le SAS.

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