Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/20 (2006.01) A61K 31/4155 (2006.01) A61P 31/18 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2515151

This invention relates to novel pyrazole derivatives of formula (I) wherein R1 to R4 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibits or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula (I) and pharmaceutical compositions of formula (I) admixed with at least one solvent, carrier or excipient. The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated (formula I).

L'invention concerne de nouveaux dérivés de pyrazole représentés par la formule (I) dans laquelle R1 à R4 sont tels que définis dans la description. L'invention concerne également leurs sels et solvates acceptables sur le plan pharmaceutique, des procédés d'inhibition ou de modulation de la transcriptase inverse du virus de l'immunodéficience humaine? ¿(VIH) avec des composés de formule (I) et des compositions pharmaceutiques contenant cette formule mélangée à au moins un solvant, un véhicule ou un excipient. Ces composés sont utiles dans le traitement de troubles dans lesquels le VIH et des virus d'origine génétique sont impliqués.

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