Non-nucleoside reverse transcriptase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/40 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61P 31/18 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2612573

Compounds of Formula (I): are HIV reverse transcriptase inhibitors, wherein R1, R2, R3, R4and R5 are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

L'invention concerne des composés inhibiteurs de la transcriptase inverse du VIH de formule (I), dans laquelle R1, R2, R3, R4 et R5 sont définis dans la description. Ces composés de formule (I) et leurs sels pharmaceutiquement acceptables sont utiles dans l'inhibition de la transcriptase inverse du VIH, la prophylaxie et le traitement de l'infection par le VIH ainsi que dans la prophylaxie, le retardement de l'apparition et le traitement du SIDA. Ces composés et leurs sels peuvent être utilisés comme ingrédients dans des compositions pharmaceutiques, éventuellement en association avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.

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