Non-nucleosidic coumarin derivatives as...

Details Non-nucleosidic coumarin derivatives as... Non-nucleosidic coumarin derivatives as...

C - Chemistry, Metallurgy

07

F

C07F 9/655 (2006.01) C07D 311/14 (2006.01) C07D 311/16 (2006.01) C07D 405/02 (2006.01) C07D 407/02 (2006.01) C07D 407/12 (2006.01) C07D 409/02 (2006.01) C07D 493/04 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2214835

Novel coumarin derivatives comprising a coumarin moiety linked to a non- nucleosidic backbone moiety are disclosed. The resulting molecules are typically used as photoactivate cross-linking groups when incorporated into polynucleotides as replacements for one or more of the complementary nucleoside bases present in probes used in procedures involving nucleic acid hybridization reactions.

Cette invention concerne de nouveaux dérivés de coumarine comportant une fraction de coumarine liée à une fraction squelette non nucléosidique. Les molécules résultantes servent typiquement de groupements de réticulation photosensibles lorsqu'elles sont incorporées à des polynucléotides à la place d'une ou de plusieurs bases nucléotidiques complémentaires présentes à l'intérieur de sondes utilisées dans des procédures faisant appel à des réactions d'hybridation moléculaire d'acides nucléiques.

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