A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/535 (2006.01) A61K 31/00 (2006.01) A61K 31/495 (2006.01) A61K 31/536 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01)
Patent
CA 2471543
The invention refers to the use of Reverse Transcriptase (RT) inhibitor compounds for the preparation of pharmaceutical compositions to counteract the loss of cellular differentiation in tumour and non tumour pathologies, said compound being able to bind the hydrophobic pocket on the RT subunit p66. Particularly preferred for such uses are the following compounds: nevirapine, efavirenz, delavirdine, corresponding salts and/or pharmaceutically acceptable derivatives thereof.
L'invention concerne l'utilisation de composés inhibiteurs de la transcriptase inverse (RT) pour la préparation de compositions pharmaceutiques destinées à compenser la perte de différenciation cellulaire dans des pathologies tumorales et non tumorales, lesdits composés pouvant se lier à la poche hydrophobe de la sous-unité p66 de la transcriptase inverse. A titre de composés particulièrement préférés pour lesdites utilisations, on peut citer: la névirapine, l'efavirenz, la délavirdine, des sels et/ou des dérivés correspondants pharmaceutiquement acceptables de ceux-ci.
Lavia Patrizia
Lorenzini Rodolfo Nello
Mattei Elisabetta
Nervi Clara
Palombini Guglielmo
Granito Alfredo
Istituto Superiore Di Sanita
Marks & Clerk
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