Non-nucleotide linking reagents for nucleotide probes

Details Non-nucleotide linking reagents for nucleotide probes Non-nucleotide linking reagents for nucleotide probes

C - Chemistry, Metallurgy

07

F

260/457, 195/1.1

C07F 9/06 (2006.01) C07F 9/24 (2006.01) C07F 9/28 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 1339303

A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a functional moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.

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