Non-pegylated long-circulating liposomes

Details Non-pegylated long-circulating liposomes Non-pegylated long-circulating liposomes

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/133 (2006.01) A61K 31/704 (2006.01)

Patent

CA 2511464

The present invention provides a long circulating non-pegylated liposomal doxorubicin composition for parenteral administration and a process for its preparation. The circulation time in swiss albino mice is at least 25 times longer than conventional non-liposomal compositions. The non-pegylated liposomes are stable, exhibit low toxicity and have been found to be efficacious in different tumor models.

L'invention concerne une composition de doxorubicine liposomale non PEG pour une administration parentérale et un procédé pour sa préparation. La durée de circulation dans des souris Swiss/albino est d'au moins 25 fois plus longue que celle de compositions non liposomales classiques. Les liposomes non PEG sont stables, présentent une faible toxicité et s'avèrent efficaces dans différents modèles de tumeurs.

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