A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4196 (2006.01) A61K 31/192 (2006.01) A61K 31/4192 (2006.01) A61K 31/52 (2006.01) A61K 38/17 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01) C07C 39/24 (2006.01) C07C 59/54 (2006.01) C07C 63/331 (2006.01) C07C 229/22 (2006.01) C07C 243/06 (2006.01) C07C 251/20 (2006.01) C07D 211/50 (2006.01) C07D 249/08 (2006.01) C07D 271/04 (2006.01) C07D 285/06 (2006.01) C07D 295/088 (2006.01) C07D 453/02 (2006.01) C07D 473/18 (2006.01) G01N 33/53 (2006.01) C07K 14/575 (2006.01)
Patent
CA 2539467
This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent whicg binds to the hormone moiety, rather than to the the hormone receptors. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients.
La présente invention a trait, par exemple, à des procédés pour l'inhibition ou la stimulation d'une activité d'une hormone peptidique de peptide de libération d'adrénomédulline ou de gastrine comprenant la mise en contact du peptide avec un agent modulateur non peptidique à petite molécule de l'invention. L'invention a également trait à des complexes de ces agents modulateurs avec d'autres constituants, tels que des peptides ou anticorps de blocage spécifiques aux peptides, ainsi que des compositions pharmaceutiques comportant les agents modulateurs, et des procédés d'utilisation des agents modulateurs pour le diagnostic ou le traitement de patients.
Cuttitta Frank
Martinez Alfredo
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
LandOfFree
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