Non-peptide antagonists of glp-1 receptor and methods of use

Details Non-peptide antagonists of glp-1 receptor and methods of use Non-peptide antagonists of glp-1 receptor and methods of use

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 45/08 (2006.01) A61P 3/08 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2350887

Non-peptide compounds that act as antagonists of the intestinal hormone glucagon-like peptide 1 (GLP-1) have a 9H-.beta.-carboline central motif. The compounds exhibit advantageous physical, chemical and biological properties and inhibit GLP-1 peptide binding to the GLP-1 receptor and/or prevent activation of the receptor by bound GLP-1. The invention further relates to a method of inhibiting the binding of GLP-1 to the GLP-1 receptor and a method of inhibiting the activation of the GLP-1 receptor. Intermediate compounds useful for making non-peptide GLP-1 receptor antagonists are also described.

Des composés non peptidiques, agissant comme des antagonistes du peptide 1 de type glucagon de l'hormone intestinal (GLP-1), possèdent un motif central de 9H-.beta.-carboline. Les composés, qui présentent des propriétés physiques, chimiques et biologiques avantageuses, inhibent le peptide GLP-1 se liant au récepteur GLP-1 et/ou empêchent une activation du récepteur par le GLP-1 lié. L'invention concerne en outre des techniques d'inhibition de la liaison du GLP-1 au récepteur GLP-1, et de l'activation du récepteur. Des composés intermédiaires, servant à fabriquer des antagonistes non peptidiques du récepteur GLP-1, sont également traités.

Affiliated with

Also associated with

Rating

Non-peptide antagonists of glp-1 receptor and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-peptide antagonists of glp-1 receptor and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-peptide antagonists of glp-1 receptor and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1967385