Non-peptide ccr1 receptor antagonists in combination with...

A - Human Necessities – 61 – K

Patent

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Details

A61K 45/06 (2006.01) A61K 31/495 (2006.01) A61K 38/13 (2006.01) A61K 38/17 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2417636

This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective amount of a non-peptide CCR1 receptor antagonist and a sub-nephrotoxic amount of cyclosporin A.

L'invention concerne des compositions pharmaceutiques utiles pour combattre une réaction de rejet consécutive à une transplantation cardiaque chez des mammifères. Ces compositions comprennent un excipient pharmaceutiquement acceptable, une dose thérapeutiquement efficace d'un antagoniste non peptidique du récepteur CCR1 ainsi qu'une dose sous-néphrotoxique de cyclosporine A.

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