Non-peptide gnrh agents

Details Non-peptide gnrh agents Non-peptide gnrh agents

C - Chemistry, Metallurgy

07

C

C07C 279/12 (2006.01) A61K 31/155 (2006.01) C07D 207/34 (2006.01) C07D 209/42 (2006.01) C07D 213/82 (2006.01) C07D 215/12 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01) C07D 237/24 (2006.01) C07D 261/10 (2006.01) C07D 261/18 (2006.01) C07D 307/00 (2006.01) C07D 307/68 (2006.01) C07D 307/71 (2006.01) C07D 307/77 (2006.01) C07D 307/91 (2006.01) C07D 317/68 (2006.01) C07D 319/18 (2006.01) C07D 333/38 (2006.01) C07D 333/70 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2322444

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin- releasing hormone are of general formula (I), where X1, X2, Y, and Z are defined variables. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

L'invention concerne des agents GnRH non-peptidiques capables d'inhiber l'effet de l'hormone gonadotrophine, représentés par la formule générale (I), dans laquelle X¿1?, X¿2?, Y et Z sont des variables définies. Lesdits composés et leurs multimères, promédicaments, métabolites actifs et sels pharmaceutiquement acceptables conviennent au traitement de troubles de reproduction, et de tumeurs dépendant de l'hormone stéroïde, chez les mammifères, ainsi qu'à la régulation de la fécondité, dans lesquels la suppression de la libération de gonadotrophine est indiquée. Des procédés de synthèse des composés et intermédiaires utiles dans leur préparation sont également décrits.

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