Non-peptide gnrh agents, methods and intermediates for their...

Details Non-peptide gnrh agents, methods and intermediates for their... Non-peptide gnrh agents, methods and intermediates for their...

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/497 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 5/00 (2006.01) A61P 5/04 (2006.01) C07D 307/68 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2341346

Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin- releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.

On décrit des agents non peptidiques de l'hormone de libération de la gonadotrophine (GnRH) qui sont capables d'inhiber l'effet de l'hormone de libération de la gonadotrophine. Ces composés et leurs sels pharmaceutiquement acceptables, ainsi que les multimères, les promédicaments et les métabolites actifs de ces derniers sont adaptés pour traiter les troubles de la reproduction chez les mammifères et les tumeurs dépendant des hormones stéroïdes ainsi que pour réguler la fertilité, où la suppression de la libération de la gonadotrophine est indiquée. Des procédés de synthèse de ces composés et des intermédiaires utiles pour les préparer sont également décrits.

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