C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/341 (2006.01) A61K 31/343 (2006.01) A61K 31/35 (2006.01) A61K 31/352 (2006.01) A61K 31/36 (2006.01) A61K 31/403 (2006.01) A61K 31/41 (2006.01) A61K 31/4162 (2006.01) A61K 31/4184 (2006.01) A61K 31/443 (2006.01) A61K 31/4709 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 5/02 (2006.01) C07D 307/58 (2006.01) C07D 307/68 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2449843
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin- releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
La présente invention concerne des agents GnRH non peptidiques qui sont capables d'inhiber l'effet de la gonadolibérine. Ces composés et leurs sels pharmaceutiquement acceptables, les promédicaments et les métabolites actifs de ces derniers sont adaptés pour traiter les troubles de la reproduction chez les mammifères et les tumeurs dépendant des hormones stéroïdes ainsi que pour réguler la fertilité, cas pour lequel la suppression de la libération de gonadotrophine est indiquée. Des méthodes de synthèse de ces composés et des intermédiaires utiles pour les préparer sont également présentées.
Anderes Kenna Lynn
Anderson Mark B.
Christie Lance Christopher
Do Quyen-Quyen Thuy
Feng Jun
Agouron Pharmaceuticals Inc.
Smart & Biggar
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