C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/46 (2006.01) A61K 31/341 (2006.01) A61K 31/435 (2006.01) A61K 31/4353 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2489252
Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin- releasing hormone are described. Such compounds and their pharmaceutically acceptable salts, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression o~ gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.
La présente invention concerne des agents anti-GnRH non peptidiques capables d'inhiber l'effet de l'hormone de libération de la gonadotrophine. Ces composés et leurs sels, promédicaments, métabolites actifs acceptables du point de vue pharmaceutique, conviennent au traitement des troubles de la reproduction chez les mammifères et des tumeurs qui dépendent de l'hormone stéroïde, ainsi qu'à la régulation de la fertilité, lorsque la suppression de la libération de gonadotrophine est souhaitée. L'invention a également pour objet des procédés pour synthétiser ces composés et des produits intermédiaires utiles pour leur préparation.
Anderson Mark Brian
Christie Lance Christopher
Do Quyen-Quyen Thuy
Feng Jun
Hong Yufeng
Pfizer Inc.
Smart & Biggar
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