Non-peptide nk1 receptors antagonists

Details Non-peptide nk1 receptors antagonists Non-peptide nk1 receptors antagonists

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/34 (2006.01) A61K 31/405 (2006.01) A61P 11/06 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) C07D 209/20 (2006.01) C07D 307/81 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 487/18 (2006.01)

Patent

CA 2355137

Non-peptide acetamide derivatives of Formula (I) are specific NK1 antagonists, where R is aryl, R1 and R2 are H or alkyl, m, n and q are integers from 0 to 4, X is NR8 or NHCONH, R3 and R9 are H or alkyl, R4 is naphthyl or indolyl, R5 and R2 are H or alkyl, and R6 is aryl. The compounds are useful agents for treating inflammatory and allergic disorders, pain, anxiety, depression, schizophrenia and emesis.

L'invention concerne des dérivés d'acétamide non peptidique de la formule I spécifiques des antagonistes NK¿1?. R est aryle, R?1¿ et R?2¿ sont H ou alkyle, m, n et q sont des entiers de 0 à 4, X est NR?8¿ ou NHCONH, R?3¿ et R?9¿ sont H ou alkyle, R?4¿ est naphtyle ou indolyle, R?5¿ et R?2¿ sont H ou alkyle, et R?6¿ est aryle. Les composés sont des agents utiles pour traiter des troubles inflammatoires et allergiques, la douleur, l'anxiété, la dépression, la schizophrénie et les vomissements.

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