Non-peptide tachykinin receptor antagonists

Details Non-peptide tachykinin receptor antagonists Non-peptide tachykinin receptor antagonists

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2138457

This invention encompasses methods for the treatment or prevention of a physiological disorder associated with an excess of tachykinins, which method comprises administering to a mammal in need of said treatment an effective amount of a compound of Formula I Image (I) wherein R1 and R3 are independently hydrogen, -CH3,1, Image or - , Image wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamthylenemino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

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