Non-peptidic cyclophilin binding compounds and their use

Details Non-peptidic cyclophilin binding compounds and their use Non-peptidic cyclophilin binding compounds and their use

C - Chemistry, Metallurgy

07

C

C07C 275/42 (2006.01) A61K 31/16 (2006.01) A61K 31/17 (2006.01) A61K 31/4965 (2006.01) A61P 25/28 (2006.01) C07C 275/28 (2006.01) C07C 275/30 (2006.01) C07C 275/40 (2006.01) C07C 311/21 (2006.01) C07C 321/28 (2006.01) C07C 323/62 (2006.01) C07D 241/20 (2006.01)

Patent

CA 2383086

The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.

L'invention concerne des composés non-peptidiques qui possèdent des propriétés bio-actives, comme la capacité à protéger les cellules neuronales d'autres traitements létaux ou la capacité à développer la croissance ou la régénération de cellules neuronales. Cette invention concerne en particulier, des composés qui interagissent avec ou se lient à une cyclophiline et des composés qui possèdent une activité tournée vers les cellules neuronales. L'invention concerne également des procédés d'utilisation de ces composés servant à administrer ces derniers aux animaux ou à les utiliser afin de traiter des conditions neurodégénératives.

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