C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/12 (2006.01) A61K 31/381 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) A61K 31/4406 (2006.01) A61K 31/4453 (2006.01) C07C 335/04 (2006.01) C07D 213/42 (2006.01) C07D 231/12 (2006.01) C07D 277/40 (2006.01) C07D 277/54 (2006.01) C07D 277/70 (2006.01) C07D 333/64 (2006.01)
Patent
CA 2611896
The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism that comprises said non- peptidic compounds or recognition molecules directed to said compounds, such as e.g. antibodies or chelating agents. The invention also relates to a pharmaceutical agent, especially for use in the treatment of diseases that are associated with a disturbance of the cAMP signal path, especially insipid diabetes, hypertonia, pancreatic diabetes, duodenal ulcer, asthma, heart failure, obesity, AIDS, edema, hepatic cirrhosis, schizophrenia and others. The invention also relates to the use of the inventive molecules.
Molécules non peptidiques qui modulent et en particulier inhibent l'interaction de la protéine kinase A (PKA) et de protéines d'ancrage de la protéine kinase A (AKAP), et organisme hôte ou cible qui comporte des composés non peptidiques ou des molécules de reconnaissance qui sont dirigées contre ces composés, telles que par ex. des anticorps et des chélateurs. La présente invention concerne en outre un produit pharmaceutique, en particulier pour le traitement de maladies associées à une perturbation de la voie de signalisation cAMP, dont en particulier le diabète insipide, l'hypertonie, le diabète sucré, l'ulcère duodénal, l'asthme, l'insuffisance cardiaque, l'adiposité, le SIDA, l'oedème, la cirrhose du foie, la schizophrénie et d'autres maladies. La présente invention concerne encore l'utilisation de la molécule selon la présente invention.
Christian Frank
Klussmann Enno
Meyer Sina
Rademann Joerg
Rosenthal Walter
Deeth Williams Wall Llp
Forschungsverbund Berlin E.v.
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