Non-peptidic renin inhibitors

Details Non-peptidic renin inhibitors Non-peptidic renin inhibitors

C - Chemistry, Metallurgy

07

D

167/208, 260/271

C07D 209/04 (2006.01) C07D 207/34 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 215/56 (2006.01) C07D 241/44 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1314545

Abstract Simple amides and derivatives thereof useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. The amides and derivatives are represented by the formula: Image (wherein HET is Image or a group of the formula Image where X is hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, fluoro, chloro, bromo or cyano; Y is hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, fluoro or chloro; R4 is hydrogen or (C1-C3)alkyl; n is an integer of 0 to 2; R1 is (C6-C8)cycloalkyl or i-propyl; R2 is (C3-C5)alkyl, phenyl, methylvinyl, dimethylvinyl, halovinyl, hydroxy(C1-C3)alkyl or amino(C1-C4)alkyl; and R3 is (C1-C6)alkyl or morpholinoethyl, and their pharmaceutically acceptable salts.

585722

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