Non-peptidic surrogates of the arg-gly-asp sequence and...

Details Non-peptidic surrogates of the arg-gly-asp sequence and... Non-peptidic surrogates of the arg-gly-asp sequence and...

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 31/195 (2006.01) A61K 31/445 (2006.01) A61K 38/04 (2006.01) C07C 279/08 (2006.01) C07C 279/12 (2006.01) C07C 279/14 (2006.01) C07C 323/44 (2006.01) C07D 211/60 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2117282

2117282 9309795 PCTABS00022 Non-peptidic RXD analogues are provided that inhibit biological cellular and molecular interactions which are dependent on RXD recognition, wherein X is one of the amino acid residues G, E, Y, A or F. In particular, RGD surrogates are provided having no sequence of .alpha.-natural amino acids and comprising a guanidino and a carboxyl terminal groups spaced by a chain of 11 atoms, at least 5 of which are carbon atoms. The compounds inhibit cell adhesion and are useful for the treatment of several pathological disorders, e.g., thrombosis, autoimmune diseases, metastasis, allergy, host-graft reactions and inhibition of scar tissue formation.

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