Non-peptidic surrogates of the ldv sequence and their use in...

Details Non-peptidic surrogates of the ldv sequence and their use in... Non-peptidic surrogates of the ldv sequence and their use in...

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 31/195 (2006.01) A61K 38/12 (2006.01) C07C 237/22 (2006.01) C07C 323/60 (2006.01) C07K 5/02 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2140931

Non-peptidic Leu-Asp-Val (LDV) surrogates of formula (1), wherein X1 to X5 are the same or different C, N, O or S at- oms, at least two of them being C, and the X1-X5 chain may be optionally substituted by radicals selected from halogen, hy- drocarbyl, oxo, thioxo, amino and carboxyl, or the X1-X5 chain or part thereof may form part of a heterocyclic ring, and pharmaceutically acceptable salts thereof, inhibit cellular or molecular interactions which depend on recognition of the LDV sequence, and are useful for the treatment of inflammation and disorders involving interference with cell-matrix or cell-cell dependent immune processes, such as autoimmune diseases and allergy, and inhibition of tumour progression and metastasis.

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