Non-radioactive assay of lipopolysaccharide kinases

Details Non-radioactive assay of lipopolysaccharide kinases Non-radioactive assay of lipopolysaccharide kinases

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) C12N 9/12 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2391711

The present invention involves a method of assaying for modulators of enzymes involved in the phosphorylation of the inner core oligosaccharide of LPS. In particular, the method assays for modulators, preferably inhibitors, of WaaP, a tyrosine kinase responsible for the phosphorylation of HepI of the inner core LPS. The finding that monoclonal antibody mAb 7-4 specifically recognizes the phosphate group(s) of LPS, is the basis for the development of a non-radiolabeling, ELISA-based assay for enzymes involved in the phosphorylation of LPS.

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