C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/135, 195/34.
C12N 15/00 (2006.01) A61K 39/112 (2006.01) C07K 14/255 (2006.01) C12N 1/20 (2006.01) A61K 39/00 (2006.01)
Patent
CA 1259934
NOVEL NON-REVERTING SALMONELLA LIVE VACCINES ABSTRACT OF THE DISCLOSURE: Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are pre- pared by introducing at least one modification in a gene involved in at least one, normally at least two, biosynthetic pathways, involving the production of pro- ducts which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concen- trated source of absorbable iron. The auxotrophic muta- tions have substantially reduced or nonexistent virulence while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change. Salmonella typhimurium strain SL1479 was de- posited at the ATCC on September 7, 1982 and given ATCC Accession No. 39183; Salmonella dublin strain SL1438 was deposited on September 7, 1982 at the ATCC and given ATCC Accession No. 39184. Salmonella typhi strain 531Ty was deposited at the ATCC on November 21, 1984, and granted ATCC Accession No. 39926.
496168
Board Of Trustees Of The Leland Stanford Jr. University (the)
Fetherstonhaugh & Co.
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