C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/135, 195/34.
C12N 1/20 (2006.01) A61K 39/112 (2006.01) C12N 15/00 (2006.01) C12N 15/74 (2006.01)
Patent
CA 1335661
Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification in a gene involved in at least one, normally at least two, biosynthetic pathways involving the production of products which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step, e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concen- trated source of absorbable iron. The auxotrophic mutations have substantially reduced or nonexistent virulence while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change.
593620
Borden Ladner Gervais Llp
The Board Of Trustees Of The Leland Stanford Junior University
LandOfFree
Non-reverting shigella live vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-reverting shigella live vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-reverting shigella live vaccines will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1249158