Non-sedating barbiturate compounds as neuroprotective agents

Details Non-sedating barbiturate compounds as neuroprotective agents Non-sedating barbiturate compounds as neuroprotective agents

A - Human Necessities

61

K

A61K 31/515 (2006.01)

Patent

CA 2416535

Methods of providing neuroprotection are disclosed comprising administering a non-sedative barbiturate compound in an amount sufficient to achieve neuroprotection in a mammalian subject. Preferred compounds are in the family of diphenylbarbituric acid and analogs. Preferred doses for a neuroprotective effect exceed the dosage of a corresponding sedative barbiturate without sedative side-effects such as anesthesia and death.

La présente invention concerne des procédés de neuroprotection comprenant l'administration d'un composé de barbiturique non sédatif en une quantité permettant la neuroprotection chez un sujet mammifère. Des composés préférés appartiennent à la famille de l'acide diphényl barbiturique et composés analogues. Des doses préférées ayant un effet neuroprotecteur sont supérieures aux doses administrées d'un barbiturique sédatif correspondant, sans avoir d'effets secondaires sédatifs tels que l'anesthésie et la mort.

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