C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/867 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/11 (2006.01) C12N 15/48 (2006.01)
Patent
CA 2198210
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5'LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3'LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and US region. Said retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
La présente invention concerne un vecteur rétroviral subissant une conversion du promoteur et comprenant une région 5'LTR de la structure U3-R-U5; une ou plusieurs séquences choisies dans les séquences codantes et non codantes; et une région 3'LTR à région U3 est partiellement ou totalement supprimée et remplacée par une séquence de lieurs multisites, suivie par la région R et la région U5. Ledit vecteur rétroviral subit une conversion de promoteur(s) et est utile comme véhicule de transfert de gènes pour la thérapie génique ciblée.
Gunzburg Walter Henry
Saller Robert Michael
Gsf - Forschungszentrum Fur Umwelt Und Gesundheit Gmbh
Shapiro Cohen
LandOfFree
Non self-inactivating, expression targeted retroviral vectors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non self-inactivating, expression targeted retroviral vectors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non self-inactivating, expression targeted retroviral vectors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1638513