Non-sequence complementary antiviral oligonucleotides

Details Non-sequence complementary antiviral oligonucleotides Non-sequence complementary antiviral oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 45/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2498777

Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length. Also described are methods for the prophylaxis or treatment of a viral infection in a human or animal, and a method for the prophylaxis treatment of cancer caused by oncoviruses in a human or animal. The methods typically involve administering to a human or animal in need of such treatment, a pharmacologically acceptable, therapeutically effective amount of at least oligonucleotide that does not act by a sequence complementary mode of action.

L'invention concerne des oligonucléotides à séquence aléatoire à activité antivirale, et leur utilisation en tant qu'agents antiviraux. Dans de nombreux cas, les oligonucléotides ont plus de 40 nucléotides en longueur. L'invention concerne également des méthodes de prophylaxie ou de traitement d'une infection virale chez un humain ou un animal, et une méthode de traitement prophylactique du cancer causé par des oncovirus chez un humain ou un animal. Ces méthodes consistent généralement à administrer à un humain ou à un animal ayant besoin d'un tel traitement une quantité acceptable d'un point de vue pharmacologique et efficace d'un point de vue thérapeutique d'au moins un oligonucléotide n'agissant pas par un mode d'action complémentaire de séquence.

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