Non-splicing variants of gp350/220

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/38 (2006.01) A61K 39/245 (2006.01) C07K 14/05 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2187908

Composition comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic uses.

L'invention porte sur des compositions comprenant des séquences d'ADN et d'acides aminés de variantes de gp 350, sur les vecteurs et cellules hôtes contenant lesdites séquences; sur un procédé d'obtention de protéines gp350 homogènes par recombinaison et en l'absence de production de protéine gp220; et sur des préparations pharmaceutiques contenant lesdites protéines, et leur utilisation à des fins thérapeutiques.

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