Non-squamous epithelium-specific transcription

Details Non-squamous epithelium-specific transcription Non-squamous epithelium-specific transcription

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2364314

The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific promoter or functional fragment thereof allowing for expression of a nucleic acid of interest operably linked to said promoter or functional fragment thereof in a cancer cell wherein said expression in said cancer cell is essentially carcinoma selective.

L'invention concerne le domaine du traitement et du diagnostic du cancer, notamment des carcinomes. Elle porte sur un acide nucléique recombiné et/ou isolé comprenant un promoteur spécifique du tissu ou un fragment fonctionnel de ce dernier, permettant l'expression d'un acide nucléique cible lié fonctionnel audit promoteur ou audit fragment de celui-ci, dans une cellule cancéreuse, ladite expression dans ladite cellule cancéreuse étant sensiblement sélective vis-à-vis des carcinomes.

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