C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/76 (2006.01) A61K 31/075 (2006.01) A61K 31/21 (2006.01) A61K 31/335 (2006.01) A61K 31/435 (2006.01) C07C 25/24 (2006.01) C07C 43/20 (2006.01) C07C 43/23 (2006.01) C07C 45/00 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 45/71 (2006.01) C07C 47/575 (2006.01) C07C 49/603 (2006.01) C07C 49/753 (2006.01) C07C 69/017 (2006.01) C07C 205/06 (2006.01) C07C 205/45 (2006.01) C07C 309/02 (2006.01) C07D 211/04 (2006.01) C07D 303/02 (2006.01) C07D 309/00 (2006.01) C07D 311/02 (2006.01) C07D 491/044 (2
Patent
CA 2133325
2133325 9321145 PCTABS00027 Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
Berger Tina S.
Farmer Luc
Fenical William
Hamann Lawrence G.
Jones Todd K.
Ligand Pharmaceuticals Inc.
Smart & Biggar
The Regents Of The University Of California
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