Non-steroidal antiinflammatory drug formulations for topical...

Details Non-steroidal antiinflammatory drug formulations for topical... Non-steroidal antiinflammatory drug formulations for topical...

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2299288

Topical alcoholic or aqueous alcoholic gels containing ibuprofen or other NSAIDs, such as naproxen, in substantially neutral salt form, have enhanced penetration through skin and may provide rapid pain/inflammation relief by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound. The amount of propylene glycol may be varied to adjust the initial flux of the NSAID through the skin, especially for ibuprofen, naproxen, and ketorolac.

L'invention concerne des gels alcooliques topiques ou alcooliques aqueux contenant de l'ibuprofène ou d'autres anti-inflammatoires non stéroïdiens tels que le naproxène, dans une forme salée sensiblement neutre; ces gels présentent une capacité de pénétration améliorée par la peau et peuvent posséder des propriétés de soulagement rapide d'une douleur/inflammation en comprenant dans leur formulation 2-n-nonyl-1,3-dioxolane ou un autre dérivé hydrocarbyle de 1,3-dioxolane ou 1,3-dioxanne ou d'acétal comme composé d'activation de pénétration par la peau. On peut varier la quantité de propylène glycol pour ajuster le flux initial d'anti-inflammatoires non stéroïdiens par la peau, notamment pour l'ibuprofène, le naproxène et le kétorolac.

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