C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/103 (2006.01) A61K 38/07 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2072033
3434H/2205a 18456 TITLE OF THE INVENTION NON-SUBSTRATE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ABSTRACT OF THE DISCLOSURE The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemothera- peutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein. transferase and the farnesylation of the oncogene protein Ras.
Garsky Victor M.
Gibbs Jackson B.
Pompliano David L.
Rands Elaine
Merck & Co. Inc.
Swabey Ogilvy Renault
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