Non-substrate inhibitors of farnesyl protein transferase

Details Non-substrate inhibitors of farnesyl protein transferase Non-substrate inhibitors of farnesyl protein transferase

C - Chemistry, Metallurgy

07

K

C07K 5/103 (2006.01) A61K 38/07 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2075678

3433H/2205a 18375 TITLE OF THE INVENTION NON-SUBSTRATE INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ABSTRACT OF THE DISCLOSURE The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemothera- peutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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