Non-tumorigenic mdck cell line for propagating viruses

Details Non-tumorigenic mdck cell line for propagating viruses Non-tumorigenic mdck cell line for propagating viruses

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 5/071 (2010.01) A61K 39/145 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2592120

The present invention provides novel MDCK-derived adherent non-tumorigenic cell lines that can be grown in the presence or absence of serum. The cell lines of the present invention are useful for the production of vaccine material (e.g. viruses). More specifically, the cell lines of the present invention are useful for the production of influenza viruses in general and ca/ts influenza viruses in particular. The invention further provides methods and media formulations for the adaptation and cultivation of MDCK cells such that they remain non-tumorigenic. Additionally, the present invention provides methods for the production of vaccine material (e.g. influenza virus) in the novel cell lines of the invention.

L'invention concerne de nouvelles lignées cellulaires non oncogènes adhérentes dérivées de MDCK pouvant être cultivées en présence ou en l'absence de sérum. Ces lignées cellulaires sont utiles pour produire de la matière de vaccin (par exemple, des virus). En particulier, ces lignées cellulaires sont utiles pour produire des virus de la grippe dans des virus de grippe communs, et en particulier dans des virus de grippe du chat. L'invention concerne des méthodes et des formulations de milieu destinées à l'adaptation et à la culture de telles cellules MDCK, de sorte que ces cellules restent non oncogènes. En outre, l'invention concerne des méthodes de production de matière de vaccin (par exemple, virus de la grippe) dans de nouvelles lignées cellulaires de l'invention.

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