Non-viral gene delivery system

Details Non-viral gene delivery system Non-viral gene delivery system

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/36 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2486678

The present invention concerns a composition comprising complexes of cationic chitosan oligomers derived from the cationic polysaccharide chitosan, wherein said cationic oligomers contain a weight fraction of less than 20% of oligomers with a Degree of Polymerization (DP)<10 in addition to a weight fraction of less than 20% with DP>50, and a nucleic acid. These compositions comprising well-defined cationic chitosan oligomers having a certain distribution of chain lengths, and nucleic acid are advantageous to achieve delivery of the nucleic acid into cells of a selected tissue, and to obtain in vivo expression of the desired molecules encoded for by the nucleic acid.

La présente invention concerne une composition comprenant des complexes d'oligomères de chitosane cationiques dérivés de chitosane de polysaccharide cationique, ces oligomères cationiques contenant une fraction de masse inférieure à 20% d'oligomères avec un degré de polymérisation (DP) < 10 outre une fraction de masse inférieure à 20% d'oligomères avec un DP > 50, et un acide nucléique. Ces compositions comprenant des oligomères de chitosane cationiques bien définis possédant une certaine répartition de longueurs de chaîne, et un acide nucléique permettent d'apporter cet acide nucléique dans des cellules d'un tissu sélectionné, et d'obtenir une expression in vivo des molécules recherchées codées par cet acide nucléique.

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