Non-viral vector

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/87 (2006.01) A61K 47/48 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C07K 19/00 (2006.01) C12N 9/96 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2182616

The present invention provides a non-viral vector, comprising a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. Also, provided is a method of introducing genetic material inside a specific cell comprising the administration of the non-virai vector to a human, wherein said non-viral vector comprises a cell binding component having a biotin-binding element conjugated to a biotinylated moiety. In addition, there is provided a method of delivering a cytotoxic moiety to a cell comprising the administration of the non-viral vector to a human.

Cette invention a pour objet un vecteur non viral comprenant un constituant de liaison cellulaire dans lequel un élément de fixation de la biotine est conjugué à une fraction biotinylée; ainsi qu'un procédé d'introduction de matière génétique à l'intérieur d'une cellule spécifique, qui consiste à administrer le vecteur non viral à un individu, ce vecteur non viral comprenant un constituant de liaison cellulaire dans lequel un élément de fixation de la biotine est conjugué à une fraction biotinylée. Cette invention concerne également un procédé permettant d'apporter une fraction cytotoxique à une cellule, selon lequel on administre à un individu ledit vecteur non viral.

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