Non-yellowing pharmaceutical composition

Details Non-yellowing pharmaceutical composition Non-yellowing pharmaceutical composition

A - Human Necessities

61

K

167/182

A61K 31/65 (2006.01) A61K 47/12 (2006.01)

Patent

CA 1203482

NON-YELLOWING TOPICAL PHARMACEUTICAL COMPOSITION Burt P. Koonsvitsky and Gary L. Manring ABSTRACT OF THE DISCLOSURE Topical compositions, containing tetracycline, tetracycline salts or tetracycline derivatives, which do not cause skin yellowing, are disclosed. These composi- tions are formulated such that, upon application to the skin, the tetracycline component recrystallizes in small, irregular crystals at the skin surface. Preferred com- positions are buffered at a pH between about 2.0 and 4, such as by the addition of citric acid. The method of treating skin disorders such as acne, using these com- positions is also disclosed.

390213

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