Nona and decapeptide analogs of lhrh useful as lhrh antagonists

Details Nona and decapeptide analogs of lhrh useful as lhrh antagonists Nona and decapeptide analogs of lhrh useful as lhrh antagonists

C - Chemistry, Metallurgy

07

C

260/525.3

C07C 279/14 (2006.01) C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1303627

ABSTRACT OF THE DISCLOSURE The present invention is directed to halo lower alkyl guanadino-substituted amino acids of formula (II): (II) Image wherein n is 1 or 5; R1 is halo lower alkyl; R2 is hydrogen, methyl or ethyl; and R3 is R1, methyl, ethyl or -CH2CH2OH; which are useful in the preparation of synthetic nonapeptide and decapeptide LHRH antagonist analogs.

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