Nonaprenylamine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 295/02 (2006.01) C07D 277/04 (2006.01) C07D 295/03 (2006.01) C07D 295/088 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1183136

ABSTRACT New pharmaceutically active nonaprenylamine deri- vatives having the general formula: Image (I) wherein R is a group capable of forming, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain a further hetero atom selected from the group consisting of nitrogen, oxygen and sulfur, the group R being unsubstituted or substituted with a hydrogen atom or a hydroxy lower alkyl group when it contains an additional nitrogen atom as the further hetero atom, and the pharma- ceutically acceptable acid addition salts thereof, are prepared by converting nonaprenol of the formula: Image (II) into a corresponding halide or aryl sulfonic acid ester which is thereafter reacted with a heterocyclic compound containing at least one secondary amino group and having the general formula: Image (III) wherein R has the aforesaid meaning, in the presence or absence of a base, when a pharmaceutically acceptable acid addition salt is desired, the nonaprenylamine derivative of the formula (I) thus obtained is further reacted with a pharmaceutically acceptable acid to provide the desired salt. The compounds of the invention are useful for controlling virus infection of vertebrate animals.

376058

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