C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/308, 260/267
C07D 295/02 (2006.01) C07D 277/04 (2006.01) C07D 295/03 (2006.01) C07D 295/088 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1183136
ABSTRACT New pharmaceutically active nonaprenylamine deri- vatives having the general formula: Image (I) wherein R is a group capable of forming, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may contain a further hetero atom selected from the group consisting of nitrogen, oxygen and sulfur, the group R being unsubstituted or substituted with a hydrogen atom or a hydroxy lower alkyl group when it contains an additional nitrogen atom as the further hetero atom, and the pharma- ceutically acceptable acid addition salts thereof, are prepared by converting nonaprenol of the formula: Image (II) into a corresponding halide or aryl sulfonic acid ester which is thereafter reacted with a heterocyclic compound containing at least one secondary amino group and having the general formula: Image (III) wherein R has the aforesaid meaning, in the presence or absence of a base, when a pharmaceutically acceptable acid addition salt is desired, the nonaprenylamine derivative of the formula (I) thus obtained is further reacted with a pharmaceutically acceptable acid to provide the desired salt. The compounds of the invention are useful for controlling virus infection of vertebrate animals.
376058
Komatsu Yasuhiro
Koyama Hiroyasu
Kubota Reiko
Tahara Yoshiyuki
Takahashi Toshihiro
Nisshin Flour Milling Co. Ltd.
Swabey Ogilvy Renault
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