Nonclassical antifolates

Details Nonclassical antifolates Nonclassical antifolates

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/505 (2006.01) A61K 38/05 (2006.01) C07D 471/04 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2184783

2-Amino-4-hydroxy-4,5,6,7-tetrahydropyrido[2,3-d]pyrimidine derivatives of aromatic amides, such as a benzamide or thienylcarboxamide in which the amino portion of the amide is other than L-glutamic acid are inhibitors of enzymes which utilize folic acid, in particular glycinamide ribonucleotide formyl transferase. A typical embodiment is N-(N-{4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidin-6-yl)ethyl]benzoyl}-L-.gamma.-glutamyl)-D-aspartic acid.

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