Nonclassical pyrrolo[2,3-d]pyrimidine antifolates

Details Nonclassical pyrrolo[2,3-d]pyrimidine antifolates Nonclassical pyrrolo[2,3-d]pyrimidine antifolates

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/555 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01) C07F 9/6561 (2006.01) C07F 17/02 (2006.01)

Patent

CA 2263907

Nonclassical pyrrolo[2,3-d]pyrimidine antifolates are described and claimed. Also described and claimed is a rapid analog process which enables a quick work-up of the antifolate which avoids costly and time-consuming chromatographic separation techniques. Also described and claimed are methods of treating susceptible neoplasms with these nonclassical antifolates. Also described and claimed are methods of treating psoriasis and arthritis with these nonclassical antifolates.

Cette invention se rapporte à des antifoliques non classiques de pyrrolo[2,3-d]pyrimidine. Elle se rapporte également à un procédé analogique rapide qui permet un examen rapide de l'antifolique et permet d'éviter le recours à des procédés de séparation chromatographique longs et coûteux. L'invention se rapporte en outre à des procédés de traitement de néoplasmes sensibles par ces antifoliques non classiques. L'invention se rapporte enfin à des procédés de traitement du psoriasis et de l'arthrite faisant usage de ces antifoliques non classiques.

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