A - Human Necessities – 01 – K
Patent
A - Human Necessities
01
K
A01K 67/027 (2006.01) A61K 45/00 (2006.01) A61P 3/10 (2006.01) C07K 14/705 (2006.01) C12N 15/85 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2461606
The present invention provides a transgenic non-human mammal model of autoimmune disease introduced with an OX40L gene, and a method for using said mammal for screening a therapeutic drug for the autoimmune disease. Transgenic mice wherein OX40L, one of the TNF family molecules, is constantly expressed in T cells, were constructed. These mice developed an autoimmune disease and they were found to be useful as a model of autoimmune disease. The transgenic non-human mammal that develops an autoimmune disease in the present invention can be constructed by expressing the OX40L gene under the control of T cell- specific lck promoter. The transgenic non-human mammal of the present invention develops an autoimmune disease such as interstitial pneumonia, inflammatory bowel disease, splenomegaly or lymphadenopathy, or hyperimmunoglobulinemia, and said mammal can be effectively used for screening a therapeutic drug for these autoimmune diseases.
L'invention concerne un modèle mammifère non humain transgénique d'une maladie auto-immune possédant un gène OX40L transféré, ainsi qu'une application de ce modèle au criblage d'un remède pour cette maladie auto-immune. En fabriquant des souris transgéniques qui expriment de façon constante OX40L, une des molécules de la famille TNF dans les lymphocytes T, on a découvert que ces souris souffrent de maladies auto-immunes et peuvent, par conséquent, être utilisées en tant que modèles de maladies auto-immunes. Un modèle mammifère non humain transgénique souffrant de la maladie auto-immune peut être fabriqué en exprimant le gène OX40L sous régulation par un promoteur lck spécifique du lymphocyte T. Le mammifère non humain transgénique obtenu souffre d'une maladie auto-immune telle que pneumonie interstitielle, maladie intestinale inflammatoire, splénomégalie, adénite ou hypergammaglobulinémie, et peut être efficacement utilisé dans le criblage d'un remède destiné à une telle maladie auto-immune.
Murata Kazuko
Sugamura Kazuo
Japan Science And Technology Agency
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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