Nonionic radiographic contrast agents

Details Nonionic radiographic contrast agents Nonionic radiographic contrast agents

C - Chemistry, Metallurgy

07

D

260/324, 167/36,

C07D 207/26 (2006.01) A61K 49/04 (2006.01) C07D 205/08 (2006.01) C07D 207/273 (2006.01) C07D 207/404 (2006.01) C07D 211/76 (2006.01) C07D 223/10 (2006.01) C07D 233/32 (2006.01) C07D 239/10 (2006.01) C07D 241/08 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 265/10 (2006.01) C07D 265/32 (2006.01)

Patent

CA 2029830

RA43 ABSTRACT New nonionic radiographic contrast agents having the formula Image I wherein Y is a single bond -CH2CH2-, -CH2O-, -OCH2-. -N-CH2-, -CH2N-, Image , -CH2-, -O- and -N-; Rl and R2 are the same or different and are Image , -CH2CH2OH and Image ; Image RA43 R3 and R4 are the same or different and are hydrogen, methyl or -CH2CH2OH; R5 is hydrogen, alkyl, -CH2CH2OH, CH2OH or OH and R6 is alkyl, -CH2CH2OH, CH2OH, OH or hydrogen and may be the same or different than R5 and m is zero or one with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond then m is not zero. These new contrast agents are water soluble and have desirable low osmolality properties.

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