Nonionic x-ray contrast agents, compositions and methods

Details Nonionic x-ray contrast agents, compositions and methods Nonionic x-ray contrast agents, compositions and methods

C - Chemistry, Metallurgy

07

C

C07C 237/46 (2006.01) A61K 49/04 (2006.01) C07C 213/08 (2006.01) C07C 215/12 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 207/273 (2006.01)

Patent

CA 2071505

ABSTRACT OF THE DISCLOSURE Triiodinated isophthalamide derivatives, useful as X-ray contrast agents, having at least one amide group derived from the amino-alcohol, 3-(N-2-hydroxyethyl)amino- 1,2-propanediol, which provides high water solubility and low mammalian toxicity, and methods of preparing them. Methods of preparing 3-(N-2-hydroxyethyl)amino-1,2- propanediol are provided.

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