Nonpeptide endothelin antagonists

Details Nonpeptide endothelin antagonists Nonpeptide endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 491/056 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/675 (2006.01) A61K 31/69 (2006.01) C07D 209/04 (2006.01) C07D 209/42 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07F 5/02 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2202051

Modified nonpeptide antagonists of endothelin of formula (I), wherein Rc is S(O)p-phenyl, which are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure and subarachnoid hemorrhage.

Antagonistes non peptidiques modifiés de l'endothéline de la formule (I), dans laquelle Rc représente S(O)p-phényle. Ces antagonistes sont utiles pour traiter des affections associées à des niveaux élevés d'endothéline, en particulier l'hypertension essentielle réno-vasculaire, artérielle et pulmonaire, l'infarctus cérébral, l'ischémie cérébrale, l'insuffisance cardiaque congestive et l'hémorragie sous-arachnoïdienne.

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