Nonpeptidyl integrin inhibitors having specificity for...

Details Nonpeptidyl integrin inhibitors having specificity for... Nonpeptidyl integrin inhibitors having specificity for...

C - Chemistry, Metallurgy

07

D

C07D 243/10 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 223/16 (2006.01) C07D 243/14 (2006.01) C07D 267/14 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/12 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 487/04 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2119745

Compounds of formula I (see formula I) act as nonpeptidyl platelet aggregation inhibitor are provided wherein A, D, G, N, T, U, W and X are as defined herein. These inhibitors potently inhibit fibrinogen binding to the GPIIbIIIa receptor and are provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.

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