Nonredundant split/pool synthesis of combinatorial libraries

Details Nonredundant split/pool synthesis of combinatorial libraries Nonredundant split/pool synthesis of combinatorial libraries

C - Chemistry, Metallurgy

07

B

C07B 61/00 (2006.01) B01J 19/00 (2006.01)

Patent

CA 2396740

The present invention includes methods for generating combinatorial libraries on solid phase supports in which increased productivity is achieved by pooling all common steps in synthesis without using a tracking or coding system to record the synthetic history of each compound. Methods for generating combinatorial libraries in which containers with random mixtures of solid phase particles are divided and combined together in non-random ways without the exchange of particles between containers are also provided. Various products are optionally produced in multi-stage syntheses according to the invention, such as oligomers and synthetic non-repetitive organic molecules. The methods additionally relate to the identification of each library component without adding extra synthetic, physical, optical, or electronic encoding steps during library synthesis. Combinatorial synthetic systems are also provided.

La présente invention concerne des procédés permettant de produire des bibliothèques combinatoires sur des supports en phase solide dans lesquels on obtient une productivité accrue en mélangeant toutes les étapes communes de la synthèse, sans avoir recours à un système de suivi ou de codage afin d'enregistrer l'historique synthétique de chaque composé. L'invention concerne également des procédés permettant de produire des bibliothèques combinatoires dans lesquelles des conteneurs renfermant des mélanges aléatoires de particules en phase solide sont divisés et combinés ensemble de manière non aléatoire sans qu'il y ait échange de particules entre les conteneurs. Différents produits sont, le cas échéant, produits dans des synthèses à étapes multiples selon l'invention, tels que des oligomères et des molécules organiques synthétiques non répétitives. Les procédés concernent également l'identification de chaque composant de la bibliothèque sans nécessiter d'étape de codage supplémentaire synthétique, physique, optique ou électronique pendant la synthèse de la bibliothèque. L'invention concerne en outre des systèmes synthétiques combinatoires.

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