Nonthrombogenic glycosaminoglycan copolymers

Details Nonthrombogenic glycosaminoglycan copolymers Nonthrombogenic glycosaminoglycan copolymers

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61L 33/00 (2006.01) A61L 33/08 (2006.01) C08G 18/64 (2006.01)

Patent

CA 2080241

2080241 9115252 PCTABS00007 New biocompatible glycosaminoglycan copolymers which are antithrombotic and antithrombogenic, are provided for demanding biomedical applications requiring long-term or permanent maintenance of anticoagulant properties. The novel copolymers of the present invention are comprised of small fragments or segments of glycosaminoglycans such as heparin, copolymerized with synthetic monomeric components. The invention takes advantage of the fact that small segments of heparin, or other glycosaminoglycans, possess and retain antithrombotic activity that retards or prevents the thrombosis. The anticoagulant fragments are conveniently produced by enzymatic or chemical means and copolymerized with synthetic monomers.

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